Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 15/20 | 0.47 |
| ▸ | RET | P07949 | 2/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.41 |
| ▸ | SRC | P12931 | 2/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | HCK | P08631 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16783846 | 0.91 | RET (0.42) | PIK3CDRETPIK3CBPIK3CAPIK3CG | |
| SCHEMBL16783573 | 0.84 | KDM4E (0.41) | PIK3CDRETPIK3CBPIK3CAPIK3CG | |
| SCHEMBL16783540 | 0.83 | PIK3CD (0.46) | PIK3CDRETPIK3CBPIK3CAPIK3CG | |
| SCHEMBL16783509 | 0.83 | PIK3CD (0.59) | PIK3CDPIK3CBPIK3CAPIK3CGSRC | |
| SCHEMBL21337779 | 0.80 | PIK3CD (0.47) | PIK3CDRETPIK3CBPIK3CAPIK3CG | |
| SCHEMBL21337762 | 0.78 | PIK3CD (0.45) | PIK3CDPIK3CBPIK3CAPIK3CG | |
| SCHEMBL21337805 | 0.76 | PIK3CD (0.56) | PIK3CDPIK3CBPIK3CAPIK3CG | |
| SCHEMBL21337793 | 0.76 | PIK3CD (0.45) | PIK3CDPIK3CBPIK3CG | |
| SCHEMBL21337767 | 0.76 | PIK3CD (0.47) | PIK3CDRETPIK3CBPIK3CGSRC | |
| SCHEMBL24494698 | 0.76 | PIK3CD (0.48) | PIK3CDPIK3CBPIK3CAPIK3CGSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3083617-B1 | ISOCHROMENE DERIVATIVES AS PHOSPHOINOSITIDE 3-KINASES INHIBITORS | CHIESI FARM SPA (IT) | 2019-09-11 | — | — | EP | disclosed |