Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 0.86 |
| ▸ | ITK | Q08881 | 10/20 | 0.86 |
| ▸ | BTK | Q06187 | 3/20 | 0.77 |
| ▸ | JAK2 | O60674 | 1/20 | 0.72 |
| ▸ | LYN | P07948 | 1/20 | 0.72 |
| ▸ | TEC | P42680 | 1/20 | 0.72 |
| ▸ | TXK | P42681 | 1/20 | 0.72 |
| ▸ | BMX | P51813 | 1/20 | 0.72 |
| ▸ | JAK3 | P52333 | 1/20 | 0.72 |
| ▸ | CD69 | Q07108 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29722291 | 0.93 | EGFR (1.00) | EGFRITKBTKJAK2LYN | |
| SCHEMBL13165707 | 0.93 | EGFR (1.00) | EGFRITKBTKJAK2LYN | |
| SCHEMBL29722526 | 0.92 | EGFR (1.00) | EGFRITKBTKJAK2LYN | |
| SCHEMBL13165509 | 0.92 | EGFR (1.00) | EGFRITKBTKJAK2LYN | |
| SCHEMBL15815010 | 0.92 | EGFR (0.86) | EGFRITKBTKJAK2LYN | |
| SCHEMBL27831797 | 0.91 | EGFR (0.84) | EGFRITKBTKJAK2LYN | |
| SCHEMBL13498409 | 0.88 | EGFR (0.84) | EGFRITKBTKJAK2LYN | |
| SCHEMBL21443641 | 0.88 | EGFR (0.83) | EGFRITKBTKJAK2LYN | |
| SCHEMBL18737405 | 0.87 | EGFR (0.83) | EGFRITKBTKJAK2LYN | |
| SCHEMBL2350864 | 0.87 | EGFR (0.82) | EGFRITKBTKJAK2LYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3019496-B1 | PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS | ACEA THERAPEUTICS INC (US) | 2019-09-11 | — | — | EP | disclosed |