Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.84 |
| ▸ | ITK | Q08881 | 9/20 | 0.84 |
| ▸ | BTK | Q06187 | 4/20 | 0.76 |
| ▸ | JAK2 | O60674 | 1/20 | 0.73 |
| ▸ | LYN | P07948 | 1/20 | 0.73 |
| ▸ | TEC | P42680 | 1/20 | 0.73 |
| ▸ | TXK | P42681 | 1/20 | 0.73 |
| ▸ | BMX | P51813 | 1/20 | 0.73 |
| ▸ | JAK3 | P52333 | 1/20 | 0.73 |
| ▸ | CD69 | Q07108 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2350864 | 0.93 | EGFR (0.82) | EGFRITKBTKJAK2LYN | |
| SCHEMBL29722291 | 0.92 | EGFR (1.00) | EGFRITKBTKJAK2LYN | |
| SCHEMBL13165707 | 0.92 | EGFR (1.00) | EGFRITKBTKJAK2LYN | |
| SCHEMBL29722526 | 0.91 | EGFR (1.00) | EGFRITKBTKJAK2LYN | |
| SCHEMBL13165509 | 0.91 | EGFR (1.00) | EGFRITKBTKJAK2LYN | |
| SCHEMBL15815010 | 0.91 | EGFR (0.86) | EGFRITKBTKJAK2LYN | |
| SCHEMBL21338060 | 0.91 | EGFR (0.86) | EGFRITKBTKJAK2LYN | |
| SCHEMBL28080977 | 0.89 | BTK (0.88) | EGFRITKBTKJAK3 | |
| SCHEMBL13498409 | 0.87 | EGFR (0.84) | EGFRITKBTKJAK2LYN | |
| SCHEMBL28437843 | 0.87 | EGFR (0.77) | EGFRITKBTKJAK2LYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102740847-A | Heteroaryl compounds and uses thereof | AVILA THERAPEUTICS INC | 2012-10-17 | — | — | CN | disclosed |
| CN-102083800-A | Heteroaryl compounds and uses thereof | AVILA THERAPEUTICS AND USES TH | 2011-06-01 | — | — | CN | disclosed |