Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.65 |
| ▸ | JAK3 | P52333 | 6/20 | 0.65 |
| ▸ | JAK2 | O60674 | 3/20 | 0.65 |
| ▸ | BLK | P51451 | 2/20 | 0.65 |
| ▸ | BMX | P51813 | 2/20 | 0.65 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.62 |
| ▸ | BTK | Q06187 | 6/20 | 0.60 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.60 |
| ▸ | PLK4 | O00444 | 1/20 | 0.60 |
| ▸ | GAK | O14976 | 1/20 | 0.60 |
| ▸ | FLT3 | P36888 | 1/20 | 0.60 |
| ▸ | CTSC | P53634 | 1/20 | 0.60 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.60 |
| ▸ | ITK | Q08881 | 1/20 | 0.60 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.60 |
| ▸ | DCLK3 | Q9C098 | 1/20 | 0.60 |
| ▸ | NUAK2 | Q9H093 | 1/20 | 0.60 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16706318 | 0.91 | EGFR (0.69) | EGFRJAK3JAK2BLKBMX | |
| SCHEMBL16371031 | 0.90 | EGFR (0.68) | EGFRJAK3JAK2BLKBMX | |
| SCHEMBL16370674 | 0.90 | EGFR (0.68) | EGFRJAK3JAK2BLKBMX | |
| SCHEMBL30672842 | 0.90 | EGFR (0.68) | EGFRJAK3JAK2BLKBMX | |
| SCHEMBL30672758 | 0.89 | EGFR (0.81) | EGFRJAK3JAK2BLKBMX | |
| SCHEMBL16372156 | 0.89 | EGFR (0.81) | EGFRJAK3JAK2BLKBMX | |
| SCHEMBL16370751 | 0.88 | EGFR (0.65) | EGFRJAK3JAK2BLKBMX | |
| SCHEMBL16370374 | 0.81 | EGFR (0.63) | EGFRJAK3JAK2BLKBMX | |
| SCHEMBL21338051 | 0.81 | ITK (0.68) | EGFRJAK3BTKITK | |
| SCHEMBL16391084 | 0.81 | EGFR (0.69) | EGFRJAK3JAK2BLKBMX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3019496-B1 | PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS | ACEA THERAPEUTICS INC (US) | 2019-09-11 | — | — | EP | disclosed |