Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.72 |
| ▸ | ERBB2 | P04626 | 8/20 | 0.67 |
| ▸ | GAK | O14976 | 3/20 | 0.67 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.67 |
| ▸ | BUB1 | O43683 | 2/20 | 0.67 |
| ▸ | STK10 | O94804 | 2/20 | 0.67 |
| ▸ | ABL1 | P00519 | 2/20 | 0.67 |
| ▸ | LCK | P06239 | 2/20 | 0.67 |
| ▸ | LYN | P07948 | 2/20 | 0.67 |
| ▸ | RET | P07949 | 2/20 | 0.67 |
| ▸ | SRC | P12931 | 2/20 | 0.67 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.67 |
| ▸ | FECH | P22830 | 2/20 | 0.67 |
| ▸ | KDR | P35968 | 2/20 | 0.67 |
| ▸ | FLT3 | P36888 | 2/20 | 0.67 |
| ▸ | MAP3K1 | Q13233 | 2/20 | 0.67 |
| ▸ | ILK | Q13418 | 2/20 | 0.67 |
| ▸ | PLK4 | O00444 | 1/20 | 0.67 |
| ▸ | CIT | O14578 | 1/20 | 0.67 |
| ▸ | AURKA | O14965 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19039482 | 0.96 | EGFR (0.72) | EGFRERBB2GAKRIPK2BUB1 | |
| SCHEMBL8684647 | 0.94 | EGFR (0.77) | EGFRERBB2GAKRIPK2BUB1 | |
| SCHEMBL8684181 | 0.90 | EGFR (0.77) | EGFRERBB2GAKRIPK2BUB1 | |
| SCHEMBL1507585 | 0.89 | EGFR (0.85) | EGFRERBB2GAKRIPK2BUB1 | |
| SCHEMBL1507594 | 0.87 | EGFR (0.89) | EGFRERBB2GAKRIPK2BUB1 | |
| Hydrochloric Acid SCHEMBL1507714 | 0.86 | EGFR (0.87) | EGFRERBB2GAKRIPK2BUB1 | |
| Hydrochloric Acid SCHEMBL29607083 | 0.86 | EGFR (0.87) | EGFRERBB2GAKRIPK2BUB1 | |
| SCHEMBL18013032 | 0.86 | EGFR (0.66) | EGFRERBB2GAKRIPK2BUB1 | |
| SCHEMBL30052378 | 0.85 | EGFR (0.85) | EGFRERBB2GAKRIPK2BUB1 | |
| SCHEMBL4348479 | 0.85 | EGFR (0.85) | EGFRERBB2GAKRIPK2BUB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3760633-A1 | OXAZINO-QUINAZOLINE AND OXAZINO-QUINAZOLINE TYPE COMPOUND, PREPARATION METHOD THEREFOR, AND USES THEREOF | Beijing Scitech-MQ Pharmaceuticals Limited (CN) | 2021-01-06 | — | — | EP | disclosed |
| WO-2019170088-A1 | OXAZINO-QUINAZOLINE AND OXAZINO-QUINAZOLINE TYPE COMPOUND, PREPARATION METHOD THEREFOR, AND USES THEREOF | 北京赛特明强医药科技有限公司 | 2019-09-12 | — | — | WO | disclosed |