Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.66 |
| ▸ | ERBB2 | P04626 | 7/20 | 0.66 |
| ▸ | GAK | O14976 | 3/20 | 0.66 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.66 |
| ▸ | BUB1 | O43683 | 2/20 | 0.66 |
| ▸ | STK10 | O94804 | 2/20 | 0.66 |
| ▸ | ABL1 | P00519 | 2/20 | 0.66 |
| ▸ | LCK | P06239 | 2/20 | 0.66 |
| ▸ | LYN | P07948 | 2/20 | 0.66 |
| ▸ | RET | P07949 | 2/20 | 0.66 |
| ▸ | SRC | P12931 | 2/20 | 0.66 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.66 |
| ▸ | FECH | P22830 | 2/20 | 0.66 |
| ▸ | KDR | P35968 | 2/20 | 0.66 |
| ▸ | FLT3 | P36888 | 2/20 | 0.66 |
| ▸ | MAP3K1 | Q13233 | 2/20 | 0.66 |
| ▸ | PLK4 | O00444 | 1/20 | 0.66 |
| ▸ | CIT | O14578 | 1/20 | 0.66 |
| ▸ | AURKA | O14965 | 1/20 | 0.66 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17967502 | 0.92 | EGFR (0.76) | EGFRERBB2GAKRIPK2BUB1 | |
| SCHEMBL18012081 | 0.88 | EGFR (0.76) | EGFRERBB2GAKRIPK2BUB1 | |
| SCHEMBL1507585 | 0.88 | EGFR (0.85) | EGFRERBB2GAKRIPK2BUB1 | |
| SCHEMBL8684647 | 0.88 | EGFR (0.77) | EGFRERBB2GAKRIPK2BUB1 | |
| SCHEMBL21340494 | 0.86 | EGFR (0.72) | EGFRERBB2GAKRIPK2BUB1 | |
| SCHEMBL18013033 | 0.86 | EGFR (0.69) | EGFRABL1LCKSRCKDR | |
| SCHEMBL30052378 | 0.84 | EGFR (0.85) | EGFRERBB2GAKRIPK2BUB1 | |
| SCHEMBL4348479 | 0.84 | EGFR (0.85) | EGFRERBB2GAKRIPK2BUB1 | |
| SCHEMBL8684181 | 0.84 | EGFR (0.77) | EGFRERBB2GAKRIPK2BUB1 | |
| Hydrochloric Acid SCHEMBL1507512 | 0.83 | EGFR (0.85) | EGFRERBB2GAKRIPK2BUB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016123706-A1 | NOVEL FLUORINATED DERIVATIVES AS EGFR INHIBITORS USEFUL FOR TREATING CANCERS | TRILLIUM THERAPEUTICS INC. (CA) | 2016-08-11 | — | — | WO | disclosed |