Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 1/20 | 0.44 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.44 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.44 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.44 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.43 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.41 |
| ▸ | HTR3B | O95264 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7642010 | 0.82 | SLC2A1 (0.45) | PLAAT3PLAAT5PLAAT2PLAAT4TAAR1 | |
| SCHEMBL21344594 | 0.81 | PLAAT3 (0.43) | PLAAT3PLAAT5PLAAT2PLAAT4TAAR1 | |
| SCHEMBL24861692 | 0.80 | PLAAT3 (0.43) | PLAAT3PLAAT5PLAAT2PLAAT4TAAR1 | |
| SCHEMBL21344131 | 0.79 | PLAAT3 (0.42) | PLAAT3PLAAT5PLAAT2PLAAT4TAAR1 | |
| SCHEMBL13959630 | 0.78 | CYP4F2 (0.47) | PLAAT3PLAAT5PLAAT2PLAAT4ALDH1A1 | |
| SCHEMBL31688944 | 0.76 | FOLH1 (0.50) | FOLH1PLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL11210243 | 0.76 | MAPK1 (0.54) | ALDH1A1MAPTCYP4F2CYP4A11SMN1; SMN2 | |
| SCHEMBL7056922 | 0.76 | TAAR1 (0.45) | TAAR1ALDH1A1MAPTSMN1; SMN2SLC2A1 | |
| SCHEMBL1858600 | 0.75 | GRIK1 (0.54) | FOLH1SMN1; SMN2POLBKMT2A | |
| SCHEMBL10064171 | 0.74 | SLC6A2 (0.44) | FOLH1PLAAT3PLAAT5PLAAT2PLAAT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019173181-A1 | ALPHA-HYDROXY PHENYLACETIC ACID PHARMACOPHORE OR BIOISOSTERE MCL-1 PROTEIN ANTAGONISTS | AMGEN INC. (US) | 2019-09-12 | — | — | WO | disclosed |