Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 5/20 | 0.60 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.54 |
| ▸ | CLK2 | P49760 | 3/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.52 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.52 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.52 |
| ▸ | CLK1 | P49759 | 1/20 | 0.52 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.52 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.50 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.50 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.50 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.50 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.50 |
| ▸ | SGK2 | Q9HBY8 | 1/20 | 0.50 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL19900583 | 0.94 | ROCK2 (0.54) | ROCK2ROCK1CLK2DYRK1ACLK4 | |
| SCHEMBL18038323 | 0.85 | ROCK1 (0.73) | ROCK2ROCK1CLK2DYRK1ACLK4 | |
| SCHEMBL21348495 | 0.83 | ROCK2 (0.62) | ROCK2ROCK1CLK2DYRK1ACLK4 | |
| SCHEMBL24934337 | 0.82 | ROCK1 (0.51) | ROCK2ROCK1CLK2DYRK1ACLK4 | |
| SCHEMBL30162921 | 0.82 | ROCK1 (0.51) | ROCK2ROCK1CLK2DYRK1ACLK4 | |
| SCHEMBL21330746 | 0.82 | MAPT (0.39) | ROCK2ROCK1CLK2DYRK1ACLK4 | |
| SCHEMBL24933426 | 0.80 | ROCK1 (0.48) | ROCK2ROCK1CLK2DYRK1ACLK4 | |
| SCHEMBL19900584 | 0.79 | ROCK2 (0.51) | ROCK2ROCK1CLK2DYRK1ACLK4 | |
| Trifluoroacetic Acid SCHEMBL19900403 | 0.78 | ROCK1 (0.56) | ROCK2ROCK1CLK2DYRK1ACLK4 | |
| SCHEMBL19900439 | 0.78 | EGFR (0.47) | ROCK2ROCK1CLK2DYRK1ACLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10556898-B2 | Indazolyl-1,2,4-thiadiazolamines and related compounds for inhibition of Rho-associated protein kinase and the treatment of disease | LYCERA CORPORATION (US) | 2020-02-11 | — | — | US | disclosed |
| US-20190276447-A1 | INDAZOLYL-1,2,4-THIADIAZOLAMINES AND RELATED COMPOUNDS FOR INHIBITION OF RHO-ASSOCIATED PROTEIN KINASE AND THE TREATMENT OF DISEASE | LYCERA CORPORATION | 2019-09-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190276447-A1 | INDAZOLYL-1,2,4-THIADIAZOLAMINES AND RELATED COMPOUNDS FOR INHIBITION OF RHO-ASSOCIATED PROTEIN KINASE AND THE TREATMENT OF DISEASE | ROCK1, ROCK2, TNK2 | ROCK2 2/4885ROCK1 1/4885CLK2 693/4885 |
| US-10556898-B2 | Indazolyl-1,2,4-thiadiazolamines and related compounds for inhibition of Rho-associated protein kinase and the treatment of disease | ROCK1, ROCK2, TNK2 | ROCK2 2/4885ROCK1 1/4885CLK2 693/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.