SCHEMBL21348853

SCHEMBL21348853

CN1C(=O)c2ccc(Oc3cccc4c3C(=O)N(c3ccccc3)C4=O)cc2C1=O

nearest known ligand 0.66

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 8/20 0.57
MEN1 O00255 4/20 0.57
ALDH1A1 P00352 3/20 0.56
MAPT P10636 1/20 0.56
SMN1; SMN2 Q16637 2/20 0.55
HTT P42858 1/20 0.55
TDP1 Q9NUW8 1/20 0.55
HPGD P15428 2/20 0.53
KDM4E B2RXH2 1/20 0.52
BRD4 O60885 1/20 0.49
POLB P06746 2/20 0.47
HSPA1A P0DMV8 1/20 0.47
PABPC1 P11940 1/20 0.47
LMNA P02545 2/20 0.46
MAPK1 P28482 1/20 0.45
ESR1 P03372 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22310426 0.88 ALDH1A1 (0.56) KMT2AMEN1ALDH1A1MAPTSMN1; SMN2
SCHEMBL3822964 0.87 SMN1; SMN2 (0.61) KMT2AMEN1ALDH1A1MAPTSMN1; SMN2
SCHEMBL22315112 0.85 ALDH1A1 (0.53) KMT2AMEN1ALDH1A1MAPTSMN1; SMN2
SCHEMBL11352025 0.85 HPGD (0.67) KMT2AMEN1ALDH1A1MAPTSMN1; SMN2
SCHEMBL24450583 0.81 HPGD (0.62) KMT2AMEN1ALDH1A1MAPTSMN1; SMN2
SCHEMBL5388051 0.80 HPGD (0.61) KMT2AMEN1ALDH1A1MAPTSMN1; SMN2
SCHEMBL11696190 0.79 HPGD (0.67) KMT2AMEN1ALDH1A1SMN1; SMN2HTT
SCHEMBL22580621 0.79 ALDH1A1 (0.54) KMT2AMEN1ALDH1A1MAPTSMN1; SMN2
SCHEMBL261725 0.79 BRD4 (0.68) KMT2AMEN1ALDH1A1MAPTHTT
SCHEMBL11347532 0.78 ALDH1A1 (0.58) KMT2AMEN1ALDH1A1MAPTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190275710-A1 METHOD FOR PRODUCING TUBULAR ARTICLE Konica Minolta, Inc. (JP) 2019-09-12 US disclosed