Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WEE1 | P30291 | 20/20 | 0.52 |
| ▸ | PLK1 | P53350 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MAP3K19 | Q56UN5 | 1/20 | 0.42 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.42 |
| ▸ | PLK2 | Q9NYY3 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21349629 | 0.89 | WEE1 (0.64) | WEE1PLK1EGFRCYP3A4MAP3K19 | |
| SCHEMBL25828125 | 0.89 | WEE1 (0.43) | WEE1PLK1 | |
| SCHEMBL22851870 | 0.85 | WEE1 (0.58) | WEE1PLK1EGFRCYP3A4MAP3K19 | |
| SCHEMBL21350111 | 0.79 | WEE1 (0.64) | WEE1PLK1EGFRCYP3A4MAP3K19 | |
| SCHEMBL25576991 | 0.79 | WEE1 (0.64) | WEE1PLK1EGFRCYP3A4MAP3K19 | |
| SCHEMBL21333353 | 0.79 | WEE1 (0.65) | WEE1PLK1EGFRCYP3A4MAP3K19 | |
| SCHEMBL24881605 | 0.79 | WEE1 (0.65) | WEE1PLK1EGFRCYP3A4MAP3K19 | |
| SCHEMBL21349330 | 0.79 | WEE1 (0.65) | WEE1PLK1EGFRCYP3A4MAP3K19 | |
| SCHEMBL21350035 | 0.79 | WEE1 (0.65) | WEE1PLK1EGFRCYP3A4MAP3K19 | |
| SCHEMBL30984877 | 0.79 | WEE1 (0.65) | WEE1PLK1EGFRCYP3A4MAP3K19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023016417-A1 | 1,2-DIHYDRO-3H-PYRAZOL[3,4-D]PYRIMIDIN-3-ONE COMPOUND AS WEE-1 INHIBITOR | 微境生物医药科技(上海)有限公司 | 2023-02-16 | — | — | WO | disclosed |
| WO-2023280180-A1 | FUSED RING COMPOUND AS WEE-1 INHIBITOR | 微境生物医药科技(上海)有限公司 | 2023-01-12 | — | — | WO | disclosed |
| WO-2021252667-A1 | METHODS OF MAKING WEE1 INHIBITOR COMPOUNDS | RECURIUM IP HOLDINGS, LLC (US) | 2021-12-16 | — | — | WO | disclosed |
| WO-2019173082-A1 | SUBSTITUTED L,2-DIHYDRO-3H-PYRAZOLO[3,4-D]PYRIMIDIN-3-ONES | Zeno Royalties & Milestones, LLC (US) | 2019-09-12 | — | — | WO | disclosed |