Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A1 | P18405 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 6/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 5/20 | 0.39 |
| ▸ | PARP11 | Q9NR21 | 4/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 2/20 | 0.36 |
| ▸ | TYMS | P04818 | 1/20 | 0.36 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29587371 | 0.78 | PARP1 (0.64) | SRD5A1PARP1PARP10PARP11PDPK1 | |
| SCHEMBL6421827 | 0.78 | PARP1 (0.64) | SRD5A1PARP1PARP10PARP11PDPK1 | |
| SCHEMBL16230718 | 0.74 | PARP1 (0.39) | PARP1PARP10PARP11NISCH | |
| SCHEMBL550313 | 0.72 | NOTUM (0.44) | SRD5A1PARP1PARP10PARP11HTR7 | |
| SCHEMBL29353774 | 0.72 | NOTUM (0.44) | SRD5A1PARP1PARP10PARP11HTR7 | |
| SCHEMBL24459353 | 0.69 | SRD5A1 (0.39) | SRD5A1CYP19A1CYP11B1CYP11B2HTR7 | |
| SCHEMBL15395880 | 0.69 | SRD5A1 (0.42) | SRD5A1CYP19A1CYP11B1CYP11B2HTR7 | |
| SCHEMBL15311783 | 0.69 | NISCH (0.42) | PARP1PARP10PARP11HTR7NISCH | |
| SCHEMBL1159918 | 0.68 | PARP10 (0.59) | PARP1PARP10PARP11PDPK1 | |
| SCHEMBL16559357 | 0.66 | SRD5A1 (0.54) | SRD5A1CYP19A1CYP11B1CYP11B2TYMS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019173804-A1 | INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5), PHARMACEUTICAL PRODUCTS THEREOF, AND METHODS THEREOF | PHARMABLOCK SCIENCES (NANJING), INC. (CN) | 2019-09-12 | — | — | WO | disclosed |