Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 7/20 | 0.59 |
| ▸ | PARP1 | P09874 | 6/20 | 0.59 |
| ▸ | PARP11 | Q9NR21 | 2/20 | 0.59 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.59 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.42 |
| ▸ | TUBB | P07437 | 1/20 | 0.42 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.42 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.42 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.42 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.42 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.42 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.42 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.42 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.42 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.42 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.42 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.42 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.42 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13896338 | 0.77 | CA12 (0.56) | PARP10PARP1PARP11PDPK1CES1 | |
| Iodide SCHEMBL7869094 | 0.76 | CA12 (0.54) | PARP10PARP1PARP11PDPK1CES1 | |
| SCHEMBL8167149 | 0.75 | PARP10 (0.46) | PARP10PARP1PARP11PDPK1CYP2A6 | |
| SCHEMBL5255383 | 0.74 | PARP10 (0.59) | PARP10PARP1PARP11PDPK1HTR2C | |
| SCHEMBL21591655 | 0.74 | PARP1 (0.59) | PARP10PARP1PARP11PDPK1HTR2C | |
| SCHEMBL29369705 | 0.74 | PARP10 (1.00) | PARP10PARP1PARP11PDPK1TUBB4A | |
| SCHEMBL88901 | 0.74 | PARP1 (0.59) | PARP10PARP1PARP11PDPK1HTR2C | |
| SCHEMBL20627564 | 0.74 | PARP10 (0.59) | PARP10PARP1PARP11PDPK1HTR2C | |
| SCHEMBL1617927 | 0.74 | PDPK1 (0.59) | PARP10PARP1PARP11PDPK1HTR2C | |
| SCHEMBL67710 | 0.74 | PARP10 (1.00) | PARP10PARP1PARP11PDPK1TUBB4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0245960-A2 | Process for preparing N-acyltetrahydroisoquinoline | Takasago Perfumery Co., Ltd. (JP) | 1987-11-19 | — | — | EP | claimed |
| EP-3693366-A1 | PROCESSES FOR PREPARING ASK1 INHIBITORS | Gilead Sciences, Inc. (US) | 2020-08-12 | — | — | EP | disclosed |
| EP-3000815-B1 | ORGANOMETALLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME | SAMSUNG ELECTRONICS CO LTD (KR) | 2017-07-19 | — | — | EP | disclosed |
| US-8394789-B2 | (Dihydro)pyrrolo[2,1-α]isoquinolines | MSD OSS B.V. (NL) | 2013-03-12 | — | — | US | disclosed |
| EP-2252611-B1 | (DIHYDRO)PYRROLO[2,1-A]ISOQUINOLINES | ORGANON NV (NL) | 2011-10-05 | — | — | EP | disclosed |
| US-20110039832-A1 | DIHYDRO)PYRROLO[2,1-A]ISOQUINOLINES | N.V. ORGANON (NL) | 2011-02-17 | — | — | US | disclosed |
| EP-2252611-A1 | (DIHYDRO)PYRROLO[2,1-A]ISOQUINOLINES | N.V. Organon (NL) | 2010-11-24 | — | — | EP | disclosed |
| WO-2009098283-A1 | (DIHYDRO)PYRROLO[2,1-A]ISOQUINOLINES | N.V. ORGANON (NL) | 2009-08-13 | — | — | WO | disclosed |
| EP-0245960-A2 | Process for preparing N-acyltetrahydroisoquinoline | Takasago Perfumery Co., Ltd. (JP) | 1987-11-19 | — | — | EP | disclosed |
| EP-0245960-A2 | Process for preparing N-acyltetrahydroisoquinoline | Takasago Perfumery Co., Ltd. (JP) | 1987-11-19 | — | — | EP | disclosed |
| US-4163786-A | Thiazoloisoquinolines with coronary and respiratory effects | CHINOIN PHARMACEUTICAL AND CHEMICAL WORKS LTD. (HU) | 1979-08-07 | — | — | US | disclosed |
| US-4062850-A | Thiazoloisoquinolines with coronary and respiratory effects | CHINOIN PHARMACEUTICAL AND CHEMICAL WORKS LTD. (HU) | 1977-12-13 | — | — | US | disclosed |
| US-3979397-A | Pharmaceutically effective novel 3,4-dihydro-1,2- and 1,3-thiozolo [4,3a] is | CHINOIN PHARMACEUTICAL AND CHEMICAL WORKS LTD. (HU) | 1976-09-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110039832-A1 | DIHYDRO)PYRROLO[2,1-A]ISOQUINOLINES | PKD2, PKD1, CATSPER1 | PARP10 430/4885PARP1 433/4885PARP11 281/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.