Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 12/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 10/20 | 0.37 |
| ▸ | RICTOR | Q6R327 | 3/20 | 0.37 |
| ▸ | RPTOR | Q8N122 | 3/20 | 0.37 |
| ▸ | MAPKAP1 | Q9BPZ7 | 3/20 | 0.37 |
| ▸ | MLST8 | Q9BVC4 | 3/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.37 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.37 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | LPL | P06858 | 2/20 | 0.31 |
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.31 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30749028 | 1.00 | MTOR (0.37) | MTORPIK3CARICTORRPTORMAPKAP1 | |
| SCHEMBL16292259 | 0.77 | LPL (0.42) | LPLLIPG | |
| SCHEMBL14862714 | 0.77 | LPL (0.42) | LPLLIPG | |
| SCHEMBL24894860 | 0.75 | USP30 (0.35) | FFAR1USP30MAP3K12LPLLIPG | |
| SCHEMBL20896213 | 0.73 | MTOR (0.44) | MTORPIK3CARICTORRPTORMAPKAP1 | |
| SCHEMBL20896210 | 0.73 | MTOR (0.44) | MTORPIK3CARICTORRPTORMAPKAP1 | |
| SCHEMBL30018560 | 0.72 | TSHR (0.37) | FFAR1USP30LPLLIPG | |
| SCHEMBL1877437 | 0.72 | POLB (0.46) | MTORPIK3CAPIK3CDPIK3CBPIK3R1 | |
| SCHEMBL30748968 | 0.72 | MTOR (0.40) | MTORPIK3CARICTORRPTORMAPKAP1 | |
| SCHEMBL14701431 | 0.71 | MAP3K12 (0.37) | FFAR1USP30MAP3K12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3080113-B1 | FUSED TRICYCLIC IMIDAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY | UCB BIOPHARMA SPRL (BE) | 2019-09-18 | — | — | EP | disclosed |