Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.33 |
| ▸ | CNR2 | P34972 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | ALPG | P10696 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21352127 | 0.83 | KMT2A (0.39) | LMNAMAPTHTTTP53KMT2A | |
| SCHEMBL21352080 | 0.79 | MAPK14 (0.33) | LMNAMAPTHTTTP53KMT2A | |
| SCHEMBL21351899 | 0.75 | CNR2 (0.35) | LMNAKMT2AEPHX2CNR2ALDH1A1 | |
| SCHEMBL21352249 | 0.75 | BACE1 (0.34) | LMNAHTTKMT2AEPHX2CNR2 | |
| SCHEMBL20157564 | 0.73 | LMNA (0.42) | LMNAHTTKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL20157556 | 0.73 | LMNA (0.44) | LMNAMAPTHTTTP53KMT2A | |
| SCHEMBL21351900 | 0.73 | CNR2 (0.35) | LMNAKMT2ACNR2ALDH1A1SMN1; SMN2 | |
| SCHEMBL21352025 | 0.71 | KDM4E (0.36) | LMNAMAPTHTTTP53KMT2A | |
| SCHEMBL20158052 | 0.70 | LMNA (0.39) | LMNAHTTKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL21351930 | 0.69 | LMNA (0.39) | LMNAMAPTHTTTP53KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3539960-A1 | NITROGENOUS MACROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF | Luoxin Pharmaceutical (Shanghai) Co., Ltd. (CN) | 2019-09-18 | — | — | EP | disclosed |