Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Pirimiphos Methyl. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.68 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 5/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pirimiphos Methyl SCHEMBL26456 | 0.93 | TDP1 (0.77) | TDP1TSHRCYP3A4ALDH1A1TP53 | |
| Pirimiphos Methyl SCHEMBL7876104 | 0.93 | TDP1 (0.77) | TDP1TSHRCYP3A4ALDH1A1TP53 | |
| Pirimiphos-Ethyl SCHEMBL15347188 | 0.87 | TDP1 (0.90) | TDP1TSHRCYP3A4ALDH1A1TP53 | |
| SCHEMBL13598679 | 0.86 | TDP1 (0.87) | TDP1TSHRCYP3A4ALDH1A1TP53 | |
| SCHEMBL1901390 | 0.84 | TDP1 (0.70) | TDP1TSHRCYP3A4ALDH1A1TP53 | |
| SCHEMBL13596982 | 0.82 | TDP1 (0.65) | TDP1TSHRCYP3A4ALDH1A1TP53 | |
| Pirimiphos Methyl SCHEMBL7081499 | 0.82 | TDP1 (0.71) | TDP1TSHRCYP3A4ALDH1A1TP53 | |
| SCHEMBL8976690 | 0.81 | TDP1 (0.59) | TDP1TSHRCYP3A4ALDH1A1TP53 | |
| Pirimiphos-Ethyl SCHEMBL7869678 | 0.81 | TDP1 (1.00) | TDP1TSHRCYP3A4ALDH1A1TP53 | |
| Pirimiphos-Ethyl SCHEMBL74180 | 0.81 | TDP1 (1.00) | TDP1TSHRCYP3A4ALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019176676-A1 | PEST EXTERMINATION METHOD AND PEST EXTERMINATING COMPOSITION | 日本曹達株式会社 | 2019-09-19 | — | — | WO | claimed |
| WO-2019176676-A1 | PEST EXTERMINATION METHOD AND PEST EXTERMINATING COMPOSITION | 日本曹達株式会社 | 2019-09-19 | — | — | WO | disclosed |