Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 5/20 | 0.58 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.58 |
| ▸ | SRC | P12931 | 3/20 | 0.55 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.55 |
| ▸ | KDR | P35968 | 4/20 | 0.54 |
| ▸ | MET | P08581 | 2/20 | 0.54 |
| ▸ | AURKA | O14965 | 1/20 | 0.54 |
| ▸ | ABL1 | P00519 | 1/20 | 0.54 |
| ▸ | LCK | P06239 | 1/20 | 0.54 |
| ▸ | LYN | P07948 | 1/20 | 0.54 |
| ▸ | TEK | Q02763 | 1/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.54 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.51 |
| ▸ | KIT | P10721 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23923068 | 0.86 | PDGFRA (0.69) | PDGFRAPDGFRBKDRMETAURKA | |
| SCHEMBL4400367 | 0.83 | PDGFRB (0.72) | PDGFRAPDGFRBSRCTGFBR1FGFR2 | |
| SCHEMBL15309998 | 0.82 | SRC (0.53) | PDGFRAPDGFRBSRCTGFBR1KDR | |
| SCHEMBL22704094 | 0.80 | PDGFRB (0.53) | PDGFRAPDGFRBSRCTGFBR1KDR | |
| SCHEMBL21185626 | 0.79 | PDGFRB (0.52) | PDGFRAPDGFRBSRCTGFBR1KDR | |
| SCHEMBL21185438 | 0.78 | PDGFRB (0.51) | PDGFRAPDGFRBSRCTGFBR1KDR | |
| SCHEMBL3794599 | 0.78 | FGFR2 (0.69) | PDGFRAPDGFRBKDRMETAURKA | |
| SCHEMBL3795531 | 0.78 | PDGFRA (0.61) | PDGFRAPDGFRBSRCTGFBR1KDR | |
| SCHEMBL15309635 | 0.78 | SRC (0.55) | PDGFRAPDGFRBSRCTGFBR1KDR | |
| SCHEMBL30034748 | 0.76 | KDR (0.51) | PDGFRAPDGFRBSRCTGFBR1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019177971-A1 | ECTONUCLEOTIDE PYROPHOSPHATASE-PHOSPHODIESTERASE 1 (ENPP-1) INHIBITORS AND USES THEREOF | MAVUPHARMA, INC. (US) | 2019-09-19 | — | — | WO | disclosed |