Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.61 |
| ▸ | JAK3 | P52333 | 5/20 | 0.61 |
| ▸ | JAK2 | O60674 | 3/20 | 0.61 |
| ▸ | BLK | P51451 | 2/20 | 0.61 |
| ▸ | BMX | P51813 | 2/20 | 0.61 |
| ▸ | BTK | Q06187 | 7/20 | 0.58 |
| ▸ | CTSC | P53634 | 3/20 | 0.58 |
| ▸ | PLK4 | O00444 | 1/20 | 0.58 |
| ▸ | GAK | O14976 | 1/20 | 0.58 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.58 |
| ▸ | FLT3 | P36888 | 1/20 | 0.58 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.58 |
| ▸ | ITK | Q08881 | 1/20 | 0.58 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.58 |
| ▸ | DCLK3 | Q9C098 | 1/20 | 0.58 |
| ▸ | NUAK2 | Q9H093 | 1/20 | 0.58 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.58 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.58 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.58 |
| ▸ | JAK1 | P23458 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21375235 | 0.86 | EGFR (0.80) | EGFRJAK3JAK2BLKBMX | |
| SCHEMBL16370515 | 0.82 | EGFR (0.71) | EGFRJAK3JAK2BLKBMX | |
| SCHEMBL21375548 | 0.81 | EGFR (0.64) | EGFRJAK3JAK2BLKBMX | |
| SCHEMBL14915043 | 0.81 | BTK (0.79) | EGFRJAK3JAK2BLKBMX | |
| SCHEMBL30672758 | 0.80 | EGFR (0.81) | EGFRJAK3JAK2BLKBMX | |
| SCHEMBL16372156 | 0.80 | EGFR (0.81) | EGFRJAK3JAK2BLKBMX | |
| SCHEMBL24392979 | 0.79 | EGFR (0.68) | EGFRJAK3JAK2BLKBMX | |
| SCHEMBL29537106 | 0.79 | EGFR (0.68) | EGFRJAK3JAK2BLKBMX | |
| SCHEMBL21358184 | 0.78 | EGFR (0.65) | EGFRJAK3JAK2BLKBMX | |
| SCHEMBL21374887 | 0.78 | EGFR (0.71) | EGFRJAK3JAK2BLKBMX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019177374-A1 | 2, 4, 5-SUBSTITUTED PYRIMIDINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS EFFECTIVE INGREDIENT FOR PREVENTION OR TREATMENT OF CANCER OR INFLAMMATORY DISEASE | 포로노이바이오 주식회사 | 2019-09-19 | — | — | WO | disclosed |