Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YAP1 | P46937 | 17/20 | 0.78 |
| ▸ | LTA4H | P09960 | 2/20 | 0.46 |
| ▸ | ACACB | O00763 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21366283 | 1.00 | YAP1 (0.78) | YAP1LTA4HACACB | |
| SCHEMBL21366370 | 0.96 | YAP1 (0.79) | YAP1LTA4H | |
| SCHEMBL23296255 | 0.89 | YAP1 (0.92) | YAP1 | |
| SCHEMBL19974560 | 0.89 | YAP1 (0.92) | YAP1 | |
| SCHEMBL21358997 | 0.88 | YAP1 (0.70) | YAP1 | |
| SCHEMBL21366282 | 0.88 | YAP1 (0.70) | YAP1 | |
| SCHEMBL19982223 | 0.88 | YAP1 (1.00) | YAP1 | |
| SCHEMBL21366368 | 0.87 | YAP1 (0.69) | YAP1 | |
| SCHEMBL21359144 | 0.87 | YAP1 (0.69) | YAP1 | |
| SCHEMBL22929134 | 0.87 | YAP1 (0.76) | YAP1LTA4HACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3765015-A1 | YAP1 INHIBITORS THAT TARGET THE INTERACTION OF YAP1 WITH OCT4 | H. Lee Moffitt Cancer Center & Research Institute, Inc. (US) | 2021-01-20 | — | — | EP | disclosed |
| CN-111989100-A | YAP1 inhibitors targeting YAP1 interaction with OCT4 | H·李·莫菲特癌症中心研究有限公司 | 2020-11-24 | — | — | CN | disclosed |
| WO-2019178401-A1 | YAP1 INHIBITORS THAT TARGET THE INTERACTION OF YAP1 WITH OCT4 | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2019-09-19 | — | — | WO | disclosed |