Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
| ▸ | CTSG | P08311 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | FAAH | O00519 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21367010 | 0.83 | EPHX1 (0.33) | ELANECTSGKDM4EALDH1A1CYP3A4 | |
| SCHEMBL21358152 | 0.81 | — | — | |
| SCHEMBL21359989 | 0.79 | — | — | |
| SCHEMBL21360032 | 0.72 | ELANE (0.41) | ELANECTSGFAAH | |
| SCHEMBL15483731 | 0.70 | KMT2A (0.32) | KDM4EMEN1ALDH1A1CYP3A4MAPT | |
| SCHEMBL21366841 | 0.69 | ELANE (0.30) | ELANECTSG | |
| SCHEMBL22968579 | 0.68 | GAA (0.32) | — | |
| SCHEMBL22968577 | 0.68 | GAA (0.32) | — | |
| SCHEMBL21366843 | 0.67 | GAA (0.31) | — | |
| SCHEMBL21244731 | 0.65 | FAAH (0.30) | FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3765006-A1 | ARGINASE INHIBITORS AND METHODS OF USE | Merck Sharp&Dohme Corp. (US) | 2021-01-20 | — | — | EP | disclosed |
| WO-2019177873-A1 | ARGINASE INHIBITORS AND METHODS OF USE | MERCK SHARP & DOHME CORP. (US) | 2019-09-19 | — | — | WO | disclosed |