Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 8/20 | 0.46 |
| ▸ | F2 | P00734 | 3/20 | 0.46 |
| ▸ | CTSG | P08311 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | F13A1 | P00488 | 3/20 | 0.39 |
| ▸ | TGM2 | P21980 | 3/20 | 0.39 |
| ▸ | TGM1 | P22735 | 3/20 | 0.39 |
| ▸ | PREP | P48147 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31367138 | 0.86 | ELANE (0.48) | ELANEF2CTSGSMN1; SMN2NPC1 | |
| SCHEMBL21359919 | 0.85 | ELANE (0.44) | ELANEF2CTSGSMN1; SMN2NPC1 | |
| SCHEMBL31367146 | 0.85 | ELANE (0.44) | ELANEF2CTSGSMN1; SMN2NPC1 | |
| SCHEMBL21360032 | 0.82 | ELANE (0.41) | ELANEF2CTSGSMN1; SMN2NPC1 | |
| SCHEMBL21358152 | 0.81 | — | — | |
| SCHEMBL21358489 | 0.80 | STS (0.38) | ELANEF2CTSGSMN1; SMN2NPC1 | |
| SCHEMBL21358594 | 0.75 | NPC1 (0.36) | ELANEF2CTSGSMN1; SMN2NPC1 | |
| SCHEMBL7399283 | 0.73 | SMN1; SMN2 (0.49) | SMN1; SMN2NPC1RAB9ACYP2C19HTT | |
| SCHEMBL30591138 | 0.73 | ELANE (0.48) | ELANEF2CTSGSMN1; SMN2NPC1 | |
| SCHEMBL21360001 | 0.71 | NPSR1 (0.39) | NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3765006-A1 | ARGINASE INHIBITORS AND METHODS OF USE | Merck Sharp&Dohme Corp. (US) | 2021-01-20 | — | — | EP | disclosed |
| WO-2019177873-A1 | ARGINASE INHIBITORS AND METHODS OF USE | MERCK SHARP & DOHME CORP. (US) | 2019-09-19 | — | — | WO | disclosed |