Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | PREP | P48147 | 2/20 | 0.44 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31105176 | 0.89 | SMN1; SMN2 (0.46) | SMN1; SMN2NPC1RAB9AHTR2CCYP2C19 | |
| SCHEMBL31367138 | 0.83 | ELANE (0.48) | SMN1; SMN2NPC1RAB9AHTTHTR2C | |
| SCHEMBL9808334 | 0.82 | SMN1; SMN2 (0.43) | SMN1; SMN2NPC1RAB9AHTTHTR2C | |
| SCHEMBL20146330 | 0.81 | HTR2C (0.48) | SMN1; SMN2NPC1RAB9AHTTHTR2C | |
| SCHEMBL30069368 | 0.79 | SMN1; SMN2 (0.56) | SMN1; SMN2NPC1RAB9AHTTHTR2C | |
| SCHEMBL3710479 | 0.78 | SMN1; SMN2 (0.49) | SMN1; SMN2NPC1RAB9AHTTHTR2C | |
| SCHEMBL6286271 | 0.78 | SMN1; SMN2 (0.46) | SMN1; SMN2NPC1RAB9AHTR2CCYP2C19 | |
| SCHEMBL29053828 | 0.77 | NPC1 (0.46) | SMN1; SMN2NPC1RAB9AHTTHTR2C | |
| SCHEMBL31367121 | 0.77 | SMN1; SMN2 (0.40) | SMN1; SMN2NPC1RAB9AHTTHTR2C | |
| SCHEMBL16903468 | 0.76 | SMN1; SMN2 (0.49) | SMN1; SMN2NPC1RAB9AHTR2CCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891362-A1 | PYRROLOPYRROLONE DERIVATIVES AS INHIBITORS OF NEUTROPHIL ELASTASE | GLAXO GROUP LIMITED (GB) | 1999-01-20 | — | — | EP | disclosed |
| WO-1997036903-A1 | PYRROLOPYRROLONE DERIVATIVES AS INHIBITORS OF NEUTROPHIL ELASTASE | GLAXO GROUP LIMITED (GB) | 1997-10-09 | — | — | WO | disclosed |