SCHEMBL21363742

SCHEMBL21363742

Cc1cc(OCSO)cc(C)c1Cc1ccc(O)c(C(C)C)c1

nearest known ligand 0.69

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
THRB P10828 20/20 0.69
THRA P10827 19/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12642742 0.87 THRB (0.75) THRBTHRA
SCHEMBL13952400 0.84 THRB (0.70) THRBTHRA
SCHEMBL10064689 0.83 THRB (0.69) THRBTHRA
SCHEMBL28769044 0.82 THRB (0.67) THRBTHRA
SCHEMBL19655550 0.81 THRB (0.82) THRBTHRA
Sobetirome SCHEMBL29467327 0.81 THRB (1.00) THRBTHRA
Sobetirome SCHEMBL282119 0.81 THRB (1.00) THRBTHRA
SCHEMBL24296740 0.81 THRB (0.61) THRBTHRA
SCHEMBL19859395 0.81 THRB (0.80) THRBTHRA
SCHEMBL13703175 0.81 THRB (0.83) THRBTHRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019178023-A1 Methods of Treating or Preventing Acute Respiratory Distress Syndrome YALE UNIVERSITY (US) 2019-09-19 WO disclosed