SCHEMBL21363785

SCHEMBL21363785

C=CCc1cc2c(cc1NCc1ccccc1F)OCO2

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 2/20 0.45
CYP1A2 P05177 3/20 0.41
MAPT P10636 3/20 0.41
CYP3A4 P08684 2/20 0.41
CYP2C9 P11712 2/20 0.40
CYP2C19 P33261 2/20 0.40
L3MBTL1 Q9Y468 2/20 0.40
ALDH1A1 P00352 2/20 0.40
NPC1 O15118 5/20 0.39
MEN1 O00255 3/20 0.39
KMT2A Q03164 3/20 0.39
ADRA2B P18089 1/20 0.38
ADRA2C P18825 1/20 0.38
ATM Q13315 1/20 0.38
PLA2G1B P04054 1/20 0.38
CYP2D6 P10635 1/20 0.38
ATG4B Q9Y4P1 1/20 0.38
RAB9A P51151 4/20 0.38
NFKB1 P19838 1/20 0.38
NFKB2 Q00653 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21363792 0.85 MEN1 (0.44) HPGDCYP1A2MAPTCYP3A4CYP2C9
SCHEMBL21363786 0.83 MAPT (0.48) HPGDCYP1A2MAPTCYP3A4CYP2C9
SCHEMBL21363746 0.74 USP2 (0.44) HPGDCYP1A2MAPTCYP3A4L3MBTL1
SCHEMBL248425 0.70 TAAR1 (0.48) MAPTL3MBTL1ALDH1A1MEN1KMT2A
SCHEMBL21363751 0.69 CYP1A2 (0.41) HPGDCYP1A2MAPTCYP3A4CYP2C9
SCHEMBL21366573 0.69 NPC1 (0.54) HPGDCYP1A2MAPTCYP3A4CYP2C9
SCHEMBL13388148 0.68 TAAR1 (0.46) MAPTL3MBTL1ALDH1A1MEN1KMT2A
Bromide SCHEMBL28225195 0.68 TAAR1 (0.46) MAPTL3MBTL1ALDH1A1MEN1KMT2A
SCHEMBL28274571 0.68 TAAR1 (0.46) MAPTL3MBTL1ALDH1A1MEN1KMT2A
SCHEMBL1276635 0.67 CYP3A4 (0.55) HPGDCYP1A2MAPTCYP3A4ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019175713-A1 NEW CATECHOL MOLECULES AND THEIR USE AS INHIBITORS TO P450 RELATED METABOLIC PATHWAYS BASF CORPORATION (US) 2019-09-19 WO disclosed
WO-2019175712-A1 NEW USES FOR CATECHOL MOLECULES AS INHIBITORS TO GLUTATHIONE S-TRANSFERASE METABOLIC PATHWAYS BASF CORPORATION (US) 2019-09-19 WO disclosed