SCHEMBL21363751

SCHEMBL21363751

C=CCc1cc2c(cc1NC(O)c1ccccc1)OCO2

nearest known ligand 0.41

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.41
CYP3A4 P08684 2/20 0.41
MAPT P10636 1/20 0.41
ALDH1A1 P00352 4/20 0.37
MEN1 O00255 3/20 0.37
KMT2A Q03164 3/20 0.37
RAB9A P51151 2/20 0.37
HPGD P15428 1/20 0.37
TSHR P16473 4/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
KDM4E B2RXH2 3/20 0.36
HSD17B10 Q99714 1/20 0.36
POLB P06746 1/20 0.34
P4HB P07237 1/20 0.33
CYP2D6 P10635 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33
HTT P42858 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21363786 0.75 MAPT (0.48) CYP1A2CYP3A4MAPTALDH1A1MEN1
SCHEMBL21366573 0.74 NPC1 (0.54) CYP1A2CYP3A4MAPTALDH1A1MEN1
SCHEMBL21363793 0.69 CYP3A4 (0.41) CYP1A2CYP3A4MAPTALDH1A1MEN1
SCHEMBL21363792 0.69 MEN1 (0.44) CYP1A2CYP3A4MAPTALDH1A1MEN1
SCHEMBL21363785 0.69 HPGD (0.45) CYP1A2CYP3A4MAPTALDH1A1MEN1
SCHEMBL1276635 0.67 CYP3A4 (0.55) CYP1A2CYP3A4MAPTALDH1A1MEN1
SCHEMBL21363749 0.66 CYP3A4 (0.43) CYP1A2CYP3A4MAPTALDH1A1MEN1
SCHEMBL11783441 0.64 P4HB (0.43) CYP1A2CYP3A4MAPTALDH1A1MEN1
SCHEMBL14552348 0.64 MAOB (0.54) CYP1A2CYP3A4MAPTALDH1A1MEN1
Safrole SCHEMBL28336724 0.63 CYP3A4 (0.77) CYP1A2CYP3A4MAPTALDH1A1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019175712-A1 NEW USES FOR CATECHOL MOLECULES AS INHIBITORS TO GLUTATHIONE S-TRANSFERASE METABOLIC PATHWAYS BASF CORPORATION (US) 2019-09-19 WO disclosed