Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29833492 | 0.86 | TGFBR1 (1.00) | TGFBR1TGFBR2 | |
| SCHEMBL18005132 | 0.86 | TGFBR1 (1.00) | TGFBR1TGFBR2 | |
| SCHEMBL18005138 | 0.85 | TGFBR1 (1.00) | TGFBR1TGFBR2 | |
| SCHEMBL29833422 | 0.85 | TGFBR1 (1.00) | TGFBR1TGFBR2 | |
| SCHEMBL15639320 | 0.82 | TGFBR1 (0.53) | TGFBR1TGFBR2 | |
| SCHEMBL15638289 | 0.80 | TGFBR1 (0.51) | TGFBR1TGFBR2 | |
| SCHEMBL15639470 | 0.80 | TGFBR1 (0.51) | TGFBR1TGFBR2 | |
| SCHEMBL15638759 | 0.77 | TGFBR1 (0.48) | TGFBR1TGFBR2 | |
| SCHEMBL18069412 | 0.77 | TGFBR1 (0.85) | TGFBR1TGFBR2 | |
| SCHEMBL29833412 | 0.77 | TGFBR1 (1.00) | TGFBR1TGFBR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190284155-A1 | 2,3-Disubstituted Pyridine Compounds as TGF-Beta Inhibitors and Methods of Use | RIGEL PHARMACEUTICALS, INC. (US) | 2019-09-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190284155-A1 | 2,3-Disubstituted Pyridine Compounds as TGF-Beta Inhibitors and Methods of Use | TGFBR2, ACVR1, TGFBR1 | TGFBR1 3/4885TGFBR2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.