Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.78 |
| ▸ | ALK | Q9UM73 | 8/20 | 0.78 |
| ▸ | EML4 | Q9HC35 | 3/20 | 0.55 |
| ▸ | ROS1 | P08922 | 2/20 | 0.55 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.55 |
| ▸ | INSR | P06213 | 1/20 | 0.55 |
| ▸ | FER | P16591 | 1/20 | 0.55 |
| ▸ | LTK | P29376 | 1/20 | 0.55 |
| ▸ | BLK | P51451 | 1/20 | 0.55 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.55 |
| ▸ | BTK | Q06187 | 1/20 | 0.55 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.55 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.55 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.55 |
| ▸ | IGF1R | P08069 | 2/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.54 |
| ▸ | MET | P08581 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL21358354 | 0.96 | EGFR (0.72) | EGFRALKEML4ROS1ERBB2 | |
| SCHEMBL19027384 | 0.91 | ALK (0.82) | EGFRALKEML4ROS1ERBB2 | |
| SCHEMBL19027794 | 0.90 | ALK (0.95) | EGFRALKEML4ROS1ERBB2 | |
| SCHEMBL19027749 | 0.88 | ALK (1.00) | EGFRALKEML4ROS1ERBB2 | |
| SCHEMBL21363943 | 0.87 | ALK (0.59) | EGFRALKEML4ROS1ERBB2 | |
| SCHEMBL19027406 | 0.85 | ALK (0.73) | EGFRALKEML4ROS1ERBB2 | |
| SCHEMBL19027412 | 0.85 | ALK (0.85) | EGFRALKEML4ROS1ERBB2 | |
| SCHEMBL21364088 | 0.84 | EGFR (0.63) | EGFRALKIGF1RKCNH2 | |
| SCHEMBL19027947 | 0.84 | ALK (0.84) | EGFRALKEML4ROS1ERBB2 | |
| SCHEMBL19027405 | 0.84 | ALK (0.89) | EGFRALKEML4ROS1ERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019177375-A1 | 2, 4, 5-SUBSTITUTED PYRIMIDINE DERIVATIVES, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING CANCER COMPRISING SAME AS ACTIVE INGREDIENT | 포로노이바이오 주식회사 | 2019-09-19 | — | — | WO | disclosed |