Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 19/20 | 0.65 |
| ▸ | EGFR | P00533 | 8/20 | 0.65 |
| ▸ | INSR | P06213 | 5/20 | 0.55 |
| ▸ | EML4 | Q9HC35 | 5/20 | 0.55 |
| ▸ | ROS1 | P08922 | 3/20 | 0.55 |
| ▸ | FER | P16591 | 3/20 | 0.55 |
| ▸ | LTK | P29376 | 3/20 | 0.55 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.55 |
| ▸ | BTK | Q06187 | 3/20 | 0.55 |
| ▸ | TNK2 | Q07912 | 3/20 | 0.55 |
| ▸ | SLK | Q9H2G2 | 3/20 | 0.55 |
| ▸ | IGF1R | P08069 | 3/20 | 0.55 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.55 |
| ▸ | PLK4 | O00444 | 2/20 | 0.55 |
| ▸ | GAK | O14976 | 2/20 | 0.55 |
| ▸ | ERN1 | O75460 | 2/20 | 0.55 |
| ▸ | STK10 | O94804 | 2/20 | 0.55 |
| ▸ | ABL1 | P00519 | 2/20 | 0.55 |
| ▸ | LCK | P06239 | 2/20 | 0.55 |
| ▸ | FYN | P06241 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19027406 | 0.87 | ALK (0.73) | ALKEGFRINSREML4ROS1 | |
| SCHEMBL19027412 | 0.87 | ALK (0.85) | ALKEGFRINSREML4ROS1 | |
| SCHEMBL21363944 | 0.83 | EGFR (0.78) | ALKEGFRINSREML4ROS1 | |
| SCHEMBL19027794 | 0.81 | ALK (0.95) | ALKEGFRINSREML4ROS1 | |
| SCHEMBL19027796 | 0.80 | ALK (0.81) | ALKEGFRINSREML4ROS1 | |
| Trifluoroacetic Acid SCHEMBL21358354 | 0.79 | EGFR (0.72) | ALKEGFRINSREML4ROS1 | |
| SCHEMBL19027384 | 0.79 | ALK (0.82) | ALKEGFRINSREML4ROS1 | |
| SCHEMBL19027868 | 0.79 | ALK (0.63) | ALKEGFRINSREML4ROS1 | |
| SCHEMBL19027749 | 0.79 | ALK (1.00) | ALKEGFRINSREML4ROS1 | |
| SCHEMBL19027755 | 0.79 | ALK (0.73) | ALKEGFRINSREML4ROS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019177375-A1 | 2, 4, 5-SUBSTITUTED PYRIMIDINE DERIVATIVES, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING CANCER COMPRISING SAME AS ACTIVE INGREDIENT | 포로노이바이오 주식회사 | 2019-09-19 | — | — | WO | disclosed |