Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 14/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.57 |
| ▸ | WNT1 | P04628 | 3/20 | 0.54 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2132109 | 0.84 | CD274 (0.51) | HDAC2WNT1DYRK1A | |
| SCHEMBL2138738 | 0.81 | HDAC1 (0.70) | HDAC1HDAC3HDAC2 | |
| SCHEMBL4581935 | 0.81 | HDAC1 (0.79) | HDAC1HDAC3HDAC2KCNH2 | |
| SCHEMBL2134032 | 0.80 | HDAC1 (0.67) | HDAC1HDAC3HDAC2KCNH2 | |
| SCHEMBL4578711 | 0.79 | HDAC1 (0.84) | HDAC1HDAC3HDAC2KCNH2 | |
| SCHEMBL14082498 | 0.78 | WNT1 (0.64) | WNT1DYRK1A | |
| SCHEMBL4580198 | 0.78 | HDAC1 (0.82) | HDAC1HDAC3HDAC2KCNH2 | |
| SCHEMBL4579434 | 0.78 | HDAC1 (0.70) | HDAC1HDAC3HDAC2KCNH2 | |
| SCHEMBL4578145 | 0.77 | HDAC1 (0.64) | HDAC1HDAC3HDAC2KCNH2 | |
| SCHEMBL18670965 | 0.77 | HDAC1 (0.65) | HDAC1HDAC3HDAC2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120101147-A1 | INHIBITION OF HDAC2 TO PROMOTE MEMORY | THE GENERAL HOSPITAL CORPORATION D/B/A MASSACHUSETTS GENERAL HOSPITAL (US) | 2012-04-26 | — | — | US | disclosed |
| US-20120101147-A1 | INHIBITION OF HDAC2 TO PROMOTE MEMORY | THE GENERAL HOSPITAL CORPORATION D/B/A MASSACHUSETTS GENERAL HOSPITAL (US) | 2012-04-26 | — | — | US | disclosed |
| WO-2010065117-A1 | INHIBITION OF HDAC2 TO PROMOTE MEMORY | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2010-06-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120101147-A1 | INHIBITION OF HDAC2 TO PROMOTE MEMORY | HDAC2, HDAC1, HDAC3 | HDAC1 2/4885HDAC3 3/4885HDAC2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.