Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YAP1 | P46937 | 17/20 | 0.82 |
| ▸ | ACACB | O00763 | 1/20 | 0.47 |
| ▸ | IL2RA | P01589 | 1/20 | 0.44 |
| ▸ | ALB | P02768 | 1/20 | 0.44 |
| ▸ | IL2 | P60568 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21366274 | 1.00 | YAP1 (0.82) | YAP1ACACBIL2RAALBIL2 | |
| SCHEMBL21366434 | 0.93 | YAP1 (0.83) | YAP1ACACB | |
| SCHEMBL21366277 | 0.93 | YAP1 (0.83) | YAP1ACACB | |
| SCHEMBL21359046 | 0.92 | YAP1 (0.74) | YAP1ACACB | |
| SCHEMBL21366279 | 0.92 | YAP1 (0.82) | YAP1ACACBIL2RAALBIL2 | |
| SCHEMBL21366292 | 0.92 | YAP1 (0.82) | YAP1ACACBIL2RAALBIL2 | |
| SCHEMBL21366139 | 0.92 | YAP1 (0.74) | YAP1ACACB | |
| SCHEMBL21366358 | 0.92 | YAP1 (0.83) | YAP1ACACB | |
| SCHEMBL21366275 | 0.92 | YAP1 (0.81) | YAP1ACACBIL2RAALBIL2 | |
| SCHEMBL21366278 | 0.92 | YAP1 (0.81) | YAP1ACACBIL2RA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019178401-A1 | YAP1 INHIBITORS THAT TARGET THE INTERACTION OF YAP1 WITH OCT4 | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2019-09-19 | — | — | WO | disclosed |