Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YAP1 | P46937 | 16/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30465116 | 1.00 | YAP1 (0.73) | YAP1KMT2AGAA | |
| SCHEMBL21366483 | 1.00 | YAP1 (0.73) | YAP1KMT2AGAA | |
| SCHEMBL21366363 | 0.94 | YAP1 (0.77) | YAP1KMT2AGAA | |
| SCHEMBL21366364 | 0.94 | YAP1 (0.77) | YAP1KMT2AGAA | |
| SCHEMBL21366535 | 0.93 | YAP1 (0.69) | YAP1KMT2A | |
| SCHEMBL21358991 | 0.93 | YAP1 (0.69) | YAP1KMT2A | |
| SCHEMBL21366366 | 0.92 | YAP1 (0.71) | YAP1KMT2AGAA | |
| SCHEMBL21366135 | 0.92 | YAP1 (0.71) | YAP1KMT2AGAA | |
| SCHEMBL30465113 | 0.92 | YAP1 (0.71) | YAP1KMT2AGAA | |
| SCHEMBL24043586 | 0.92 | YAP1 (0.69) | YAP1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019178401-A1 | YAP1 INHIBITORS THAT TARGET THE INTERACTION OF YAP1 WITH OCT4 | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2019-09-19 | — | — | WO | disclosed |