Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YAP1 | P46937 | 15/20 | 0.68 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21358986 | 1.00 | YAP1 (0.68) | YAP1POLBSLC6A4SLC6A3 | |
| SCHEMBL28491331 | 0.94 | YAP1 (0.65) | YAP1POLB | |
| SCHEMBL21366536 | 0.94 | YAP1 (0.65) | YAP1POLBSLC6A4SLC6A3 | |
| SCHEMBL21366439 | 0.94 | YAP1 (0.65) | YAP1POLB | |
| SCHEMBL21359006 | 0.94 | YAP1 (0.65) | YAP1POLBSLC6A4SLC6A3 | |
| SCHEMBL21359030 | 0.94 | YAP1 (0.65) | YAP1POLB | |
| SCHEMBL21359008 | 0.94 | YAP1 (0.65) | YAP1POLB | |
| SCHEMBL21358884 | 0.93 | YAP1 (0.64) | YAP1POLB | |
| SCHEMBL21366437 | 0.93 | YAP1 (0.64) | YAP1POLB | |
| SCHEMBL21359050 | 0.92 | YAP1 (0.62) | YAP1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111989100-A | YAP1 inhibitors targeting YAP1 interaction with OCT4 | H·李·莫菲特癌症中心研究有限公司 | 2020-11-24 | — | — | CN | disclosed |
| WO-2019178401-A1 | YAP1 INHIBITORS THAT TARGET THE INTERACTION OF YAP1 WITH OCT4 | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2019-09-19 | — | — | WO | disclosed |