Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 14/20 | 0.46 |
| ▸ | WDR77 | Q9BQA1 | 14/20 | 0.46 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.38 |
| ▸ | AHCY | P23526 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18009766 | 0.89 | PRMT5 (0.43) | PRMT5WDR77 | |
| SCHEMBL18205070 | 0.86 | PRMT5 (0.42) | PRMT5WDR77 | |
| SCHEMBL22002026 | 0.85 | PRMT5 (0.41) | PRMT5WDR77 | |
| SCHEMBL18205028 | 0.84 | PRMT5 (0.42) | PRMT5WDR77 | |
| SCHEMBL18205090 | 0.83 | PRMT5 (0.40) | PRMT5WDR77 | |
| SCHEMBL24489756 | 0.83 | PRMT5 (0.41) | PRMT5WDR77ADORA3ADORA1 | |
| SCHEMBL21367135 | 0.83 | PRMT5 (0.41) | PRMT5WDR77ADORA3ADORA1 | |
| SCHEMBL21367292 | 0.83 | PRMT5 (0.41) | PRMT5WDR77ADORA3ADORA1 | |
| SCHEMBL18205046 | 0.83 | PRMT5 (0.40) | PRMT5WDR77 | |
| SCHEMBL21367163 | 0.83 | PRMT5 (0.41) | PRMT5WDR77ADORA3ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3765461-B1 | SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5) | PRELUDE THERAPEUTICS INC (US) | 2023-08-30 | — | — | EP | disclosed |
| WO-2019178368-A1 | SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5) | PRELUDE THERAPEUTICS, INCORPORATED (US) | 2019-09-19 | — | — | WO | disclosed |