Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.31 |
| ▸ | HTR2C | P28335 | 2/20 | 0.31 |
| ▸ | HTR2B | P41595 | 2/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22517653 | 0.90 | MEN1 (0.33) | HPGD | |
| SCHEMBL21355872 | 0.77 | DUT (0.31) | — | |
| SCHEMBL21356261 | 0.77 | TAAR1 (0.32) | TAAR1 | |
| SCHEMBL29384390 | 0.77 | TAAR1 (0.32) | TAAR1 | |
| SCHEMBL16044441 | 0.76 | NOTUM (0.32) | TAAR1 | |
| SCHEMBL16045515 | 0.76 | ABL1 (0.34) | HPGD | |
| SCHEMBL21355870 | 0.75 | — | — | |
| SCHEMBL16047584 | 0.74 | — | — | |
| SCHEMBL3840051 | 0.72 | MEN1 (0.38) | HPGD | |
| SCHEMBL23139889 | 0.72 | TAAR1 (0.34) | HTR2AHTR2CHTR2BTAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3765461-B1 | SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5) | PRELUDE THERAPEUTICS INC (US) | 2023-08-30 | — | — | EP | disclosed |
| WO-2019178368-A1 | SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5) | PRELUDE THERAPEUTICS, INCORPORATED (US) | 2019-09-19 | — | — | WO | disclosed |