Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29277327 | 0.82 | MAPT (0.49) | MAPTALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL554424 | 0.82 | MAPT (0.49) | MAPTALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL23704334 | 0.76 | NTRK1 (0.39) | MAPTALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL29994070 | 0.76 | NTRK1 (0.39) | MAPTALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL3114251 | 0.76 | MAPT (0.53) | MAPTALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL1683322 | 0.75 | GPR3 (0.57) | MAPTALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL16727188 | 0.75 | MAPT (0.56) | MAPTALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL16639005 | 0.74 | MAPT (0.46) | MAPTALDH1A1KDM4EHPGDHSD17B10 | |
| Hydrochloric Acid SCHEMBL30379478 | 0.73 | NQO2 (0.54) | MAPTALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL23606081 | 0.72 | HRH3 (0.47) | MAPTALDH1A1KDM4EHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019178129-A1 | SUBSTITUTED IMIDAZOPYRIDINES AS INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2019-09-19 | — | — | WO | disclosed |