Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 15/20 | 0.85 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22623435 | 1.00 | GLS (0.85) | GLSTP53POLBTSHRL3MBTL1 | |
| SCHEMBL14987279 | 0.92 | GLS (1.00) | GLS | |
| SCHEMBL14987282 | 0.91 | GLS (0.86) | GLS | |
| SCHEMBL21466345 | 0.90 | GLS (0.87) | GLS | |
| SCHEMBL22031569 | 0.90 | GLS (0.87) | GLS | |
| SCHEMBL14987543 | 0.89 | GLS (0.78) | GLSTP53POLBTSHRL3MBTL1 | |
| SCHEMBL15724907 | 0.87 | GLS (0.78) | GLSTP53POLBTSHRL3MBTL1 | |
| SCHEMBL21369065 | 0.86 | GLS (0.87) | GLS | |
| SCHEMBL21484186 | 0.85 | GLS (0.81) | GLS | |
| SCHEMBL21486517 | 0.85 | GLS (0.81) | GLS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2782570-B1 | HETEROCYCLIC INHIBITORS OF GLUTAMINASE | CALITHERA BIOSCIENCES INC (US) | 2019-09-18 | — | — | EP | disclosed |