Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 19/20 | 0.73 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19920088 | 0.91 | GLS (0.75) | GLS | |
| SCHEMBL14987105 | 0.85 | GLS (0.76) | GLS | |
| SCHEMBL15043773 | 0.85 | GLS (1.00) | GLS | |
| SCHEMBL19920086 | 0.83 | GLS (0.78) | GLS | |
| SCHEMBL14987544 | 0.79 | GLS (1.00) | GLS | |
| SCHEMBL14987276 | 0.78 | GLS (0.78) | GLS | |
| SCHEMBL15043796 | 0.77 | GLS (1.00) | GLS | |
| SCHEMBL14987280 | 0.73 | GLS (0.80) | GLS | |
| SCHEMBL15043819 | 0.71 | GLS (1.00) | GLS | |
| SCHEMBL18122440 | 0.70 | GLS (0.77) | GLS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3277276-B1 | METHODS OF ADMINISTERING GLUTAMINASE INHIBITORS | CALITHERA BIOSCIENCES INC (US) | 2020-11-04 | — | — | EP | disclosed |
| EP-2782570-B1 | HETEROCYCLIC INHIBITORS OF GLUTAMINASE | CALITHERA BIOSCIENCES INC (US) | 2019-09-18 | — | — | EP | disclosed |