Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 17/20 | 0.81 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14987536 | 0.90 | GLS (1.00) | GLSALDH1A1MAPTNPSR1 | |
| SCHEMBL18137164 | 0.85 | GLS (0.89) | GLSALDH1A1MAPTNPSR1 | |
| SCHEMBL14987538 | 0.82 | GLS (1.00) | GLS | |
| SCHEMBL21369060 | 0.82 | GLS (0.79) | GLS | |
| SCHEMBL14987277 | 0.76 | GLS (1.00) | GLSALDH1A1MAPT | |
| SCHEMBL14987545 | 0.76 | GLS (1.00) | GLSALDH1A1MAPT | |
| SCHEMBL14987416 | 0.74 | GLS (1.00) | GLSALDH1A1MAPT | |
| SCHEMBL22031630 | 0.73 | GLS (0.79) | GLS | |
| SCHEMBL21369062 | 0.68 | GLS (0.81) | GLSALDH1A1MAPT | |
| SCHEMBL14987539 | 0.68 | GLS (1.00) | GLS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2782570-B1 | HETEROCYCLIC INHIBITORS OF GLUTAMINASE | CALITHERA BIOSCIENCES INC (US) | 2019-09-18 | — | — | EP | disclosed |