Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ascorbic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.81 |
| ▸ | MAPT | P10636 | 2/20 | 0.81 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.81 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.48 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.48 |
| ▸ | TST | Q16762 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | TYR | P14679 | 2/20 | 0.42 |
| ▸ | MANBA | O00462 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ascorbic Acid SCHEMBL21372601 | 0.97 | MAPT (0.81) | LMNAMAPTL3MBTL1HSPD1HSPE1 | |
| Ascorbic Acid SCHEMBL21372605 | 0.97 | MAPT (0.81) | LMNAMAPTL3MBTL1HSPD1HSPE1 | |
| Ascorbic Acid SCHEMBL10535642 | 0.94 | MAPT (0.76) | LMNAMAPTL3MBTL1HSPD1HSPE1 | |
| Ascorbic Acid SCHEMBL23683559 | 0.93 | MAPT (0.69) | LMNAMAPTL3MBTL1HSPD1HSPE1 | |
| Ascorbic Acid SCHEMBL29619513 | 0.93 | MAPT (0.69) | LMNAMAPTL3MBTL1HSPD1HSPE1 | |
| Ascorbic Acid SCHEMBL165191 | 0.92 | MAPT (0.78) | LMNAMAPTL3MBTL1HSPD1HSPE1 | |
| Ascorbic Acid SCHEMBL29857583 | 0.92 | MAPT (0.83) | LMNAMAPTL3MBTL1HSPD1HSPE1 | |
| Ascorbic Acid SCHEMBL5968922 | 0.92 | MAPT (0.83) | LMNAMAPTL3MBTL1HSPD1HSPE1 | |
| Ascorbic Acid SCHEMBL29992966 | 0.92 | MAPT (0.89) | LMNAMAPTL3MBTL1HSPD1HSPE1 | |
| Ascorbic Acid SCHEMBL4146647 | 0.92 | MAPT (0.96) | LMNAMAPTL3MBTL1HSPD1HSPE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190327961-A1 | STABLE SOLID COMPOSITION BASED ON AN AROMATIC COMPOUND AND USES THEREOF | REMMAL, ADNANE (MA) | 2019-10-31 | — | — | US | claimed |
| EP-3541182-A1 | STABLE SOLID COMPOSITION BASED ON AN AROMATIC COMPOUND AND USES THEREOF | Remmal, Adnane (MA) | 2019-09-25 | — | — | EP | claimed |
| US-20190327961-A1 | STABLE SOLID COMPOSITION BASED ON AN AROMATIC COMPOUND AND USES THEREOF | REMMAL, ADNANE (MA) | 2019-10-31 | — | — | US | disclosed |
| EP-3541182-A1 | STABLE SOLID COMPOSITION BASED ON AN AROMATIC COMPOUND AND USES THEREOF | Remmal, Adnane (MA) | 2019-09-25 | — | — | EP | disclosed |