Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 12/20 | 0.41 |
| ▸ | CYP3A5 | P20815 | 7/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 3/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.35 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21372840 | 0.84 | IDO1 (0.57) | IDO1 | |
| SCHEMBL21372682 | 0.83 | IDO1 (0.52) | IDO1 | |
| SCHEMBL21373045 | 0.81 | IDO1 (0.42) | IDO1 | |
| SCHEMBL21372927 | 0.81 | IDO1 (0.47) | IDO1BRD4 | |
| SCHEMBL18225041 | 0.80 | CYP3A4 (0.49) | CYP3A4CYP3A5 | |
| SCHEMBL21373039 | 0.80 | IDO1 (0.41) | IDO1BRD4 | |
| SCHEMBL18236924 | 0.80 | CYP3A4 (0.49) | CYP3A4CYP3A5 | |
| SCHEMBL21372968 | 0.80 | IDO1 (0.41) | IDO1CYP3A4BRD4 | |
| SCHEMBL18225039 | 0.80 | CYP3A4 (0.49) | CYP3A4CYP3A5 | |
| SCHEMBL21373044 | 0.80 | MKNK1 (0.39) | IDO1CYP3A4CYP3A5CSNK1DCSNK1E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3294732-B1 | BENZIMIDAZOLE AND IMADAZOPYRIDINE CARBOXIMIDAMIDE COMPOUNDS HAVING ACTIVITY AS INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE | GILEAD SCIENCES INC (US) | 2019-09-25 | — | — | EP | claimed |