Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 9/20 | 0.39 |
| ▸ | TDO2 | P48775 | 2/20 | 0.37 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.36 |
| ▸ | HTR3B | O95264 | 2/20 | 0.36 |
| ▸ | HTR3A | P46098 | 2/20 | 0.36 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.36 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.36 |
| ▸ | POLA1 | P09884 | 2/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | PBK | Q96KB5 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.33 |
| ▸ | ITGAV | P06756 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21372781 | 0.91 | IDO1 (0.42) | IDO1TDO2BRAFPBKCYP3A4 | |
| SCHEMBL21372682 | 0.90 | IDO1 (0.52) | IDO1TDO2BRAF | |
| SCHEMBL21372804 | 0.87 | IDO1 (0.38) | IDO1TDO2PBKCYP3A4 | |
| SCHEMBL21372664 | 0.86 | ALDH1A1 (0.47) | IDO1PBKCYP3A4 | |
| SCHEMBL21372902 | 0.86 | IDO1 (0.46) | IDO1TDO2HTR3EHTR3BHTR3A | |
| SCHEMBL21372855 | 0.83 | CYP3A4 (0.44) | IDO1PBKCYP3A4 | |
| SCHEMBL21372864 | 0.82 | CYP3A4 (0.38) | PBKCYP3A4 | |
| SCHEMBL21373009 | 0.81 | HTT (0.40) | IDO1PBKCYP3A4 | |
| SCHEMBL21373044 | 0.81 | MKNK1 (0.39) | IDO1PBKCYP3A4 | |
| SCHEMBL21372715 | 0.81 | IDO1 (0.46) | IDO1TDO2BRAFPBKCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3294732-B1 | BENZIMIDAZOLE AND IMADAZOPYRIDINE CARBOXIMIDAMIDE COMPOUNDS HAVING ACTIVITY AS INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE | GILEAD SCIENCES INC (US) | 2019-09-25 | — | — | EP | claimed |