Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 10/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 8/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 8/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 7/20 | 0.44 |
| ▸ | TSHR | P16473 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 6/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.42 |
| ▸ | CLK2 | P49760 | 3/20 | 0.42 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | PAK4 | O96013 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7614422 | 0.75 | CLK4 (0.49) | CLK4CYP1A2CYP2D6CYP3A4CYP2C19 | |
| SCHEMBL30501033 | 0.71 | KDM4E (0.59) | CLK4CYP1A2CYP2D6CYP3A4CYP2C19 | |
| SCHEMBL20380088 | 0.71 | KDM4E (0.59) | CLK4CYP1A2CYP2D6CYP3A4CYP2C19 | |
| SCHEMBL21387798 | 0.68 | CLK4 (0.50) | CLK4CYP1A2CYP2D6CYP3A4CYP2C19 | |
| SCHEMBL22162812 | 0.67 | CA12 (0.58) | CYP3A4ALDH1A1KDM4EPOLBLMNA | |
| SCHEMBL6923809 | 0.67 | CA12 (0.54) | CLK4TSHRALDH1A1KDM4EPOLB | |
| SCHEMBL21565692 | 0.66 | CLK4 (0.48) | CLK4CYP1A2CYP2D6CYP3A4CYP2C19 | |
| SCHEMBL22404289 | 0.66 | CLK4 (0.50) | CLK4CYP1A2CYP2D6CYP3A4CYP2C19 | |
| SCHEMBL22404287 | 0.66 | CYP3A4 (0.48) | CLK4CYP1A2CYP2D6CYP3A4CYP2C19 | |
| SCHEMBL21373604 | 0.66 | QPCT (0.37) | CYP3A4ALDH1A1KDM4EMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3543231-A1 | COMPOUNDS FOR TREATING CNS- AND NEURODEGENERATIVE DISEASES | ETH Zurich (CH) | 2019-09-25 | — | — | EP | claimed |
| EP-3568133-B1 | CELL-PROTECTIVE COMPOUNDS AND THEIR USE | ETH ZUERICH (CH) | 2023-12-13 | — | — | EP | disclosed |
| CN-116462666-A | Cytoprotective compounds and uses thereof | 瑞士苏黎世联邦理工学院 | 2023-07-21 | — | — | CN | disclosed |
| EP-3543231-A1 | COMPOUNDS FOR TREATING CNS- AND NEURODEGENERATIVE DISEASES | ETH Zurich (CH) | 2019-09-25 | — | — | EP | disclosed |