SCHEMBL21374095

SCHEMBL21374095

Cc1ccc(-c2ccc(-c3cc(F)c(C(F)(F)Oc4cc(F)c(F)c(F)c4)c(F)c3)c(F)c2F)cc1C

nearest known ligand 0.36

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 4/20 0.36
PTGS1 P23219 2/20 0.36
AKR1C3 P42330 3/20 0.34
AKR1C2 P52895 3/20 0.34
AKR1B10 O60218 2/20 0.32
AKR1C4 P17516 2/20 0.32
AKR1C1 Q04828 2/20 0.32
ALOX5AP P20292 1/20 0.32
FEN1 P39748 1/20 0.32
FFAR4 Q5NUL3 2/20 0.31
CNR1 P21554 1/20 0.30
CNR2 P34972 1/20 0.30
PDE3B Q13370 1/20 0.30
PDE3A Q14432 1/20 0.30
FFAR1 O14842 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18324924 0.92 AKR1C3 (0.37) PTGS2PTGS1AKR1C3AKR1C2AKR1B10
SCHEMBL20380566 0.91 AKR1C3 (0.32) AKR1C3AKR1C2
SCHEMBL18324919 0.89 PTGS2 (0.34) PTGS2PTGS1
SCHEMBL18324930 0.88 PTGS2 (0.33) PTGS2PTGS1
SCHEMBL20380706 0.87 AKR1C3 (0.32) PTGS2PTGS1AKR1C3AKR1C2AKR1B10
SCHEMBL20380622 0.87 RPS6KA3 (0.35) PTGS2PTGS1AKR1C3AKR1C2ALOX5AP
SCHEMBL18324942 0.85 AKR1C3 (0.37) PTGS2PTGS1AKR1C3AKR1C2AKR1B10
SCHEMBL20380717 0.85 ALOX5AP (0.36) AKR1C3AKR1C2ALOX5APFEN1FFAR4
SCHEMBL18324935 0.85 PTGS2 (0.34) PTGS2PTGS1
SCHEMBL18855112 0.84 AKR1C3 (0.34) PTGS2PTGS1AKR1C3AKR1C2AKR1B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190284475-A1 LIQUID CRYSTAL COMPOUND AND A LIQUID CRYSTAL COMPOSITION INCLUDING THE SAME DAXIN MATERIALS CORP. (TW) 2019-09-19 US disclosed