Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.46 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.46 |
| ▸ | POLA1 | P09884 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | NT5E | P21589 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ALB | P02768 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20782390 | 1.00 | KDM4E (0.58) | KDM4ETAS1R3TAS1R1POLA1ALDH1A1 | |
| SCHEMBL21637043 | 1.00 | KDM4E (0.58) | KDM4ETAS1R3TAS1R1POLA1ALDH1A1 | |
| SCHEMBL21636987 | 0.92 | KDM4E (0.53) | KDM4ETAS1R3TAS1R1POLA1ALDH1A1 | |
| SCHEMBL23487519 | 0.90 | KDM4E (0.59) | KDM4ETAS1R3TAS1R1POLA1ALDH1A1 | |
| SCHEMBL19146280 | 0.90 | KDM4E (0.59) | KDM4ETAS1R3TAS1R1POLA1ALDH1A1 | |
| SCHEMBL24222098 | 0.90 | KDM4E (0.59) | KDM4ETAS1R3TAS1R1POLA1ALDH1A1 | |
| SCHEMBL22883498 | 0.90 | KDM4E (0.59) | KDM4ETAS1R3TAS1R1POLA1ALDH1A1 | |
| SCHEMBL28719205 | 0.90 | KDM4E (0.59) | KDM4ETAS1R3TAS1R1POLA1ALDH1A1 | |
| SCHEMBL18521398 | 0.86 | KDM4E (0.71) | KDM4ETAS1R3TAS1R1POLA1ALDH1A1 | |
| SCHEMBL20154878 | 0.86 | KDM4E (0.71) | KDM4ETAS1R3TAS1R1POLA1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3936514-B1 | 3'3' CYCLIC DINUCLEOTIDES WITH AN ALKENYLENE | INST OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR V V I (CZ) | 2023-05-24 | — | — | EP | disclosed |
| WO-2022007986-A1 | 3'3' CYCLIC DINUCLEOTIDES WITH AN ALKENYLENE | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY AS CR, V. V. I. (CZ) | 2022-01-13 | — | — | WO | disclosed |
| EP-3922637-A1 | MODIFIED OLIGONUCLEOTIDES FOR USE IN TREATMENT OF TAUOPATHIES | Janssen Pharmaceutica NV (BE) | 2021-12-15 | — | — | EP | disclosed |
| WO-2019175260-A2 | MODIFIED OLIGONUCLEOTIDES AND METHODS OF USE IN TAUOPATHIES | JANSSEN PHARMACEUTICA NV (BE) | 2019-09-19 | — | — | WO | disclosed |