Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 9/20 | 0.70 |
| ▸ | KDM4A | O75164 | 5/20 | 0.70 |
| ▸ | KDM4B | O94953 | 5/20 | 0.70 |
| ▸ | KDM5B | Q9UGL1 | 5/20 | 0.70 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.63 |
| ▸ | MAPT | P10636 | 3/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | KDM5C | P41229 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21376917 | 0.93 | GRM1 (0.76) | ADORA3KDM4AKDM4BKDM5BGRM1 | |
| SCHEMBL21376508 | 0.92 | ADORA3 (0.74) | ADORA3KDM4AKDM4BKDM5BGRM1 | |
| SCHEMBL21376789 | 0.91 | GRM1 (0.63) | ADORA3KDM4AKDM4BKDM5BGRM1 | |
| SCHEMBL21376797 | 0.89 | ADORA3 (0.60) | ADORA3KDM4AKDM4BKDM5BGRM1 | |
| SCHEMBL21376527 | 0.88 | ADORA3 (0.67) | ADORA3KDM4AKDM4BKDM5BGRM1 | |
| SCHEMBL21376512 | 0.86 | ADORA3 (0.66) | ADORA3KDM4AKDM4BKDM5BGRM1 | |
| SCHEMBL31361484 | 0.81 | ADORA3 (0.90) | ADORA3KDM4AKDM4BKDM5BGRM1 | |
| SCHEMBL663246 | 0.81 | MEN1 (0.71) | ADORA3KDM4AKDM4BKDM5BGRM1 | |
| SCHEMBL18997292 | 0.81 | GRM1 (1.00) | ADORA3KDM4AKDM4BKDM5BGRM1 | |
| SCHEMBL21909785 | 0.80 | ADORA3 (0.67) | ADORA3KDM4AKDM4BKDM5BGRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2403499-B1 | METHODS AND COMPOSITIONS FOR USE IN TREATING CANCER AND REDUCING WNT MEDIATED EFFECTS IN A CELL | STEMSYNERGY THERAPEUTICS INC (US) | 2019-09-18 | — | — | EP | disclosed |