Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 20/20 | 0.84 |
| ▸ | IDH2 | P48735 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21378525 | 1.00 | IDH1 (0.84) | IDH1IDH2 | |
| SCHEMBL19692693 | 0.92 | IDH1 (1.00) | IDH1IDH2 | |
| SCHEMBL19692695 | 0.92 | IDH1 (1.00) | IDH1IDH2 | |
| SCHEMBL21378515 | 0.90 | IDH1 (0.78) | IDH1IDH2 | |
| SCHEMBL19701039 | 0.90 | IDH1 (0.78) | IDH1IDH2 | |
| SCHEMBL21378390 | 0.89 | IDH1 (0.76) | IDH1 | |
| SCHEMBL19701052 | 0.89 | IDH1 (0.76) | IDH1 | |
| SCHEMBL21378371 | 0.82 | IDH1 (0.85) | IDH1IDH2 | |
| SCHEMBL21378370 | 0.82 | IDH1 (0.85) | IDH1IDH2 | |
| SCHEMBL19701075 | 0.82 | IDH1 (0.82) | IDH1IDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464281-B1 | MUTANT IDH1 INHIBITORS | LILLY CO ELI (US) | 2020-07-08 | — | — | EP | disclosed |
| US-10696665-B2 | Mutant IDH1 inhibitors | ELI LILLY AND COMPANY (US) | 2020-06-30 | — | — | US | disclosed |
| US-20190292175-A1 | MUTANT IDH1 INHIBITORS | ELI LILLY AND COMPANY | 2019-09-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10696665-B2 | Mutant IDH1 inhibitors | IDH1, IDH3B, IDH3A | IDH1 1/4885IDH2 4/4885 |
| US-20190292175-A1 | MUTANT IDH1 INHIBITORS | IDH1, IDH3B, IDH3A | IDH1 1/4885IDH2 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.