Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1B | Q00975 | 3/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.40 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.40 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.40 |
| ▸ | DPP7 | Q9UHL4 | 7/20 | 0.39 |
| ▸ | DPP4 | P27487 | 6/20 | 0.39 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23211957 | 1.00 | CACNA1B (0.42) | CACNA1BSLC6A3CACNA2D1CACNB1CACNA1C | |
| SCHEMBL23211960 | 0.88 | EPHX2 (0.39) | CACNA1BSLC6A3CACNA2D1CACNB1CACNA1C | |
| SCHEMBL21381935 | 0.88 | EPHX2 (0.39) | CACNA1BSLC6A3CACNA2D1CACNB1CACNA1C | |
| SCHEMBL21384762 | 0.85 | MMP13 (0.49) | DPP4KMT2A | |
| SCHEMBL23211893 | 0.85 | MMP13 (0.49) | DPP4KMT2A | |
| SCHEMBL23211958 | 0.81 | CACNA1B (0.40) | CACNA1BSLC6A3CACNA2D1CACNB1CACNA1C | |
| SCHEMBL21381705 | 0.81 | CACNA1B (0.40) | CACNA1BSLC6A3DPP7DPP8KCNH2 | |
| SCHEMBL23212057 | 0.81 | CACNA1B (0.43) | CACNA1BCACNA2D1CACNB1CACNA1CDPP7 | |
| SCHEMBL4395343 | 0.81 | IDO1 (0.47) | CACNA1BCACNA2D1CACNB1CACNA1CDPP7 | |
| SCHEMBL29068375 | 0.80 | CACNA1B (0.41) | CACNA1BSLC6A3CACNA2D1CACNB1CACNA1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3768684-A1 | OXAZINE MONOACYLGLYCEROL LIPASE (MAGL) INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2021-01-27 | — | — | EP | disclosed |
| WO-2019180185-A1 | OXAZINE MONOACYLGLYCEROL LIPASE (MAGL) INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2019-09-26 | — | — | WO | disclosed |