Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | CACNA2D1 | P54289 | 4/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.35 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.35 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21381738 | 0.85 | POLB (0.36) | LMNATSHRCACNA2D1SLC6A2KMT2A | |
| SCHEMBL21061235 | 0.84 | MEN1 (0.39) | TSHRCACNA2D1SLC6A2CARM1PRMT6 | |
| SCHEMBL15234415 | 0.76 | TSHR (0.50) | LMNATSHRCACNA2D1CARM1PRMT6 | |
| SCHEMBL5914983 | 0.75 | TSHR (0.49) | LMNATSHRCACNA2D1CARM1PRMT6 | |
| SCHEMBL5914993 | 0.75 | TSHR (0.49) | LMNATSHRCACNA2D1CARM1PRMT6 | |
| SCHEMBL5914985 | 0.75 | TSHR (0.49) | LMNATSHRCACNA2D1CARM1PRMT6 | |
| SCHEMBL4438408 | 0.75 | NPC1 (0.47) | LMNATSHRCACNA2D1CARM1PRMT6 | |
| SCHEMBL4440875 | 0.75 | NPC1 (0.47) | LMNATSHRCACNA2D1CARM1PRMT6 | |
| SCHEMBL4448649 | 0.75 | NPC1 (0.47) | LMNATSHRCACNA2D1CARM1PRMT6 | |
| SCHEMBL15247731 | 0.73 | CARM1 (0.46) | LMNATSHRCACNA2D1SLC6A2CARM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020021021-A1 | ORTHO SUBSTITUTED PHENOXYPROPYLAMINO AND BENZYLOXYPROPYLAMINO DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2020-01-30 | — | — | WO | disclosed |
| WO-2019180189-A1 | AMINOPROPOXYPHENYL AND BENZYL 3,4-DIHYDRO-2H-SPIRO[ISOQUINOLINE-1,4'-PIPERIDIN]-1'-YL DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2019-09-26 | — | — | WO | disclosed |