Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21061215 | 0.85 | TP53 (0.35) | POLBTP53LMNATHRBNPSR1 | |
| SCHEMBL21382346 | 0.85 | LMNA (0.41) | LMNATSHRKMT2ACACNA2D1TAAR1 | |
| SCHEMBL21051931 | 0.82 | CACNA2D1 (0.45) | POLBTP53LMNATHRBNPSR1 | |
| SCHEMBL20917472 | 0.81 | CACNA2D1 (0.41) | LMNATHRBALDH1A1KMT2ANPC1 | |
| SCHEMBL22367190 | 0.81 | CACNA2D1 (0.41) | LMNATHRBALDH1A1KMT2ANPC1 | |
| SCHEMBL21381740 | 0.77 | TSHR (0.37) | POLBTSHRRAB9AKMT2ANPC1 | |
| SCHEMBL20292716 | 0.77 | CACNA2D1 (0.48) | ALDH1A1KMT2ACACNA2D1SLC6A2SLC6A4 | |
| SCHEMBL5915026 | 0.77 | LMNA (0.39) | POLBTP53LMNATHRBNPSR1 | |
| SCHEMBL5915024 | 0.77 | LMNA (0.39) | POLBTP53LMNATHRBNPSR1 | |
| SCHEMBL6271962 | 0.77 | LMNA (0.39) | POLBTP53LMNATHRBNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020021021-A1 | ORTHO SUBSTITUTED PHENOXYPROPYLAMINO AND BENZYLOXYPROPYLAMINO DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2020-01-30 | — | — | WO | disclosed |
| WO-2019180189-A1 | AMINOPROPOXYPHENYL AND BENZYL 3,4-DIHYDRO-2H-SPIRO[ISOQUINOLINE-1,4'-PIPERIDIN]-1'-YL DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2019-09-26 | — | — | WO | disclosed |