Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.52 |
| ▸ | CNR1 | P21554 | 17/20 | 0.49 |
| ▸ | CNR2 | P34972 | 5/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL212276 | 0.88 | TRPV1 (0.46) | TRPV1CNR1CNR2HDAC4HDAC6 | |
| SCHEMBL214048 | 0.83 | CNR1 (0.68) | CNR1CNR2 | |
| SCHEMBL4681584 | 0.79 | CNR1 (0.55) | TRPV1CNR1CNR2 | |
| SCHEMBL4677448 | 0.79 | CNR1 (0.55) | TRPV1CNR1CNR2 | |
| SCHEMBL4677453 | 0.79 | CNR1 (0.55) | TRPV1CNR1CNR2 | |
| SCHEMBL4681579 | 0.79 | CNR1 (0.55) | TRPV1CNR1CNR2 | |
| SCHEMBL4677450 | 0.79 | CNR1 (0.55) | TRPV1CNR1CNR2 | |
| SCHEMBL4677622 | 0.76 | CNR1 (0.52) | TRPV1CNR1CNR2 | |
| SCHEMBL4677901 | 0.76 | CNR1 (0.52) | TRPV1CNR1CNR2 | |
| SCHEMBL4677619 | 0.76 | CNR1 (0.52) | TRPV1CNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088920-B2 | 3-trifluoromethyl-pyrazine-2-carboxylic acid amide derivatives as HDL-cholesterol raising agents | HOFFMANN-LA ROCHE INC. (US) | 2012-01-03 | — | — | US | disclosed |
| EP-2271632-A1 | 3-TRIFLUOROMETHYL-PYRAZINE-2-CARBOXYLIC ACID AMIDE DERIVATIVES AS HDL-CHOLESTEROL RAISING AGENTS | F. Hoffmann-La Roche AG (CH) | 2011-01-12 | — | — | EP | disclosed |