Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL212405 | 0.91 | CNR1 (0.61) | CNR1CNR2 | |
| SCHEMBL212661 | 0.90 | CNR1 (0.61) | CNR1CNR2 | |
| SCHEMBL14856849 | 0.87 | CNR1 (0.62) | CNR1CNR2 | |
| SCHEMBL214387 | 0.87 | CNR1 (0.61) | CNR1CNR2 | |
| SCHEMBL2702757 | 0.83 | CNR1 (0.67) | CNR1CNR2 | |
| SCHEMBL213838 | 0.83 | TRPV1 (0.52) | CNR1CNR2 | |
| SCHEMBL1018532 | 0.82 | CNR1 (0.46) | CNR1CNR2 | |
| SCHEMBL211995 | 0.82 | CNR1 (0.56) | CNR1CNR2 | |
| SCHEMBL213558 | 0.81 | CNR1 (0.55) | CNR1CNR2 | |
| SCHEMBL10031414 | 0.78 | CNR1 (0.61) | CNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088920-B2 | 3-trifluoromethyl-pyrazine-2-carboxylic acid amide derivatives as HDL-cholesterol raising agents | HOFFMANN-LA ROCHE INC. (US) | 2012-01-03 | — | — | US | claimed |
| EP-2271632-A1 | 3-TRIFLUOROMETHYL-PYRAZINE-2-CARBOXYLIC ACID AMIDE DERIVATIVES AS HDL-CHOLESTEROL RAISING AGENTS | F. Hoffmann-La Roche AG (CH) | 2011-01-12 | — | — | EP | claimed |
| WO-2012031817-A1 | DETERMINATION OF ABCA1 PROTEIN LEVELS IN CELLS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-03-15 | — | — | WO | disclosed |
| US-8088920-B2 | 3-trifluoromethyl-pyrazine-2-carboxylic acid amide derivatives as HDL-cholesterol raising agents | HOFFMANN-LA ROCHE INC. (US) | 2012-01-03 | — | — | US | disclosed |